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KMID : 0604520110370040357
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Journal of the Society of Cosmetic Scientists of Korea
2011 Volume.37 No. 4 p.357 ~ p.363
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Antioxidative Effect and Tyrosinase Inhibitory Activity of Rheum undulatum L. Extracts
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Kim Jung-Eun
Park Chan-Ha
Oh Dae-Seok
Lee Seung-Yeon
Jang Se-Hun
Hong Jee-Yeon
Min Hye-Jin
Park Su-Ah
Won Doo-Hyun
Park Soo-Nam
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Abstract
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In this study, the antioxidative effects and inhibitory activities on tyrosinase of Rheum undulatum (R.undulatum) L. extracts were investigated. 50 % ethanol extract, ethyl acetate and aglycone fractions of R. undulatum L. were used in experiments. The DPPH (1,1-diphenyl-2-picrylhydrazyl) scavenging activities (FSC50) of R. undulatum L. extracts was lower than (+)-α-tocopherol, known as a typical antioxidant. Reactive oxygen species (ROS) scavenging activities (OSC50) of aglycone fraction on ROS generated in Fe3+-EDTA/H2O2 system using the luminol-dependent chemiluminescence assay showed the most prominent effect at a concentration of 0.265 μg/mL. The cellular protective effects of extract/fractions of R. undulatum L. on the rose-bengal sensitized photohemolysis of human erythrocytes were increased in a concentration dependent manner (1 ~ 50 μg/mL). Especially, aglycone fraction in 10 μg/mL concentration showed the most protective effect among extracts (τ50, 757.0 min). The inhibitory effects (IC50, 11.20 μg/mL) on tyrosinase of aglycone fraction was much higher than arbutin (226.88 μg/mL), known as a whitening agent. These results indicate that R. undulatum L. extracts can be used as antioxidant. Particularly, aglycone fraction of R. undulatum L. showed superior antioxdative activity and high inhibitory effect on tyrosinase. Therefore, aglycone fraction of R. undulatum L. could be applicable to new functional cosmetics.
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KEYWORD
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R. undulatum L., antioxidative activity, tyrosinase, cosmetics
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